Thursday, September 11, 2008

Hereditary cancer?

http://misc.medscape.com/pi/editorial/dmeflash/2008/17063/nccn-cancerriskevaluation.pdf - This article provides the guideline for patient referrals for genetic counseling for cancer - breast and ovarian are on page 1; colorectal is on page 2. Specifically, for colorectal cancer:

RED FLAGS:
- Personal history of early-age-onset colorectal cancer (< 50 years of age)
- Personal or family history of multiple colorectal carcinomas
- Personal or family history of polyposis (> 10 adenomas) in the same individual
- Personal history or family history of more than 1 hereditary non-polyposis colorectal cancer
(HNPCC)-related cancer (eg, colon and uterine cancer) in the same individual
- Personal history of an HNPCC-related cancer and:
o One or more first-degree relative with HNPCC-related cancer prior to age 50
o Two or more first- or second-degree relatives with an HNPCC-related cancer
diagnosed at any age
- Personal or family history of a hereditary syndrome associated with cancer (eg, HNPCC,
FAP, MYH-associated polyposis, Peutz-Jeghers syndrome, juvenile polyposis) with or
without a known mutation
-HNPCC (also known as Lynch syndrome)-related cancers include: Colorectal; Endometrial; Ovarian; Duodenal/small bowel; Stomach; Sebaceous adenomas or sebaceous carcinomas; Ureteral/Renal pelvis; Hepatobiliary/pancreatic; and Brain tumors (particularly glioblastomas)
DEFINITIONS
􀂃 First-degree relative: parent, sibling, child
􀂃 Second-degree relative: aunt, uncle, niece, nephew, grandparents
􀂃 Third-degree relative: first cousin, great aunts, great uncles

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